Azadeh Soltanifar; Roya Samadi; Mohsen Pasandideh; Naghmeh Mokhber; Fatemeh Moharari; Atefeh Soltanifar
Volume 19, Issue 3 , September and October 2012, , Pages 228-237
Abstract
Background: ADHD is one of the most common neuropsychiatric disorders in children. Methylphenidate is the most frequent medication prescribed for this disorder, while bupropion is suggested as an alternative for treatment. This research aims to compare the efficacy and safety of bupropion and methylphenidate ...
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Background: ADHD is one of the most common neuropsychiatric disorders in children. Methylphenidate is the most frequent medication prescribed for this disorder, while bupropion is suggested as an alternative for treatment. This research aims to compare the efficacy and safety of bupropion and methylphenidate (Ritalin) in children with ADHD. Materials and Methods: Forty children with ADHD, aged 6 to 12 years, from consecutive referrals to child psychiatric clinic of Ibn-e-Sina hospital were selected and randomly divided into two categories (treatment with methylphenidate or bupropion). Evaluations were carried out based on ADHD Rating Scale (by teacher and parent) and Global Clinical Scale (by clinician) at the beginning of the study and again after 4 and 8 weeks of the study. Adverse effects were also checked at 4 and 8 weeks. Data was analyzed using SPSS software, version 11.5. Results: Data was normally distributed in the two categories in terms of demographic and quantitative variables. Therapeutic response, in parents’ views, was better in Ritalin group and was significantly different at the end of the 8th week (p=0.014). Ritalin was also more efficacious in teachers’ views, but had no significant advantage (p=0.092). Global clinical scale showed a significant advantage in both categories regarding response to therapy (p=0.014). Therapy was seen efficacious by parents, teachers, and clinician (p
Fatemeh Moharreri; Atefeh Soltanifar; Azadeh Soltanifar
Volume 19, Issue 1 , March and April 2012, , Pages 6-13
Abstract
Background: The core symptoms of autism are abnormalities in social interaction, communication, and behavior. The involvement of 5-HT has been suggested in neuropsychiatric disorders and particularly in autistic disorder.
Material and Methods: The aim of this study was to assess the efficacy of cyproheptadine, ...
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Background: The core symptoms of autism are abnormalities in social interaction, communication, and behavior. The involvement of 5-HT has been suggested in neuropsychiatric disorders and particularly in autistic disorder.
Material and Methods: The aim of this study was to assess the efficacy of cyproheptadine, a 5-HT2 antagonist, in the treatment of autistic disorder. In this double-blind, placebo-controlled trial, we assessed the effects of cyproheptadine plus risperidone in the treatment of autistic disorder.
: Thirty children between the ages of 3 and 11 years (inclusive) with a DSM-IV-TR clinical diagnosis of autism referred to the child psychiatry clinics at Sheikh and Ebn-e Sina hospitals, Mashhad, were recruited. The children presented with severely disruptive symptoms related to autistic disorder. Patients were randomly allocated to cyproheptadine + risperidone (Group A; 15 patients) and risperidone + placebo (Group B; 15 patients) for an 8-week, double-blind, placebo-controlled study. The doses of risperidone and cyproheptadine were titrated up to 2 mg/day and 0.2 mg/kg/day, respectively. Patients were assessed at baseline and after 4 and 8 weeks of starting medications.
Results: The Childhood Autism Rating Scale scores after 4 and 8 weeks were 40.26±2.9 and 38.56±2.38 in group A and 40.2±3.31 and 37.73±2.59 in group B, respectively. The scores improved in both groups, but the difference between them was not significant (F=0.029, d.f= 1, p=0.867).
Conclusion: The results suggest that the combination of cyproheptadine with risperidone is not more effective than risperidone alone. However, the results need confirmation by a larger randomized controlled trial.
Atefeh Soltanifar; Vahideh Moghadam Hoseini; Farzaneh Jafarnejad; Saeed Ebrahimzadeh
Volume 16, Issue 1 , March and April 2009, , Pages 35-42
Abstract
Background and Purpose: Mother–infant attachment has gained momentum in mental health in recent years. Also partner violence against pregnant women is an important health problem all over the world. The present study was designed to determine the relationship between domestic violence intensity in ...
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Background and Purpose: Mother–infant attachment has gained momentum in mental health in recent years. Also partner violence against pregnant women is an important health problem all over the world. The present study was designed to determine the relationship between domestic violence intensity in pregnancy and mother-infant attachment. Methods and Materials: In this deh1ive analytical study 102 pregnant women admitted to healthcare centers in Mashad in 2008 were included through stratified clustered sampling. Information on domestic violence during pregnancy was collected through "Conflict Tactics Scale" and "Mother to Infant Attachment Inventory" 4-5 weeks after delivery. Obtained data were analyzed in SPSS using Spearman correlation coefficient Kruskal Wallis Mann Whitney U and multiple regression. Results: In general 89.2% of women experienced very mild 9.8% experienced mild and 1% moderate levels of domestic experience from their partners. Negative significant relationships were found to exist between verbal (p=0.032 r= - 0/21) and physical violence (p=0.005 r= - 0.27) injuries (p=0.018 r= - 0.23) total score of violence (p=0.002 r= - 0.29) and mother-infant attachment. Also mean scores of psychological (p=0.026 ms=15/9±12/94) and physical (p=0.002 ms=9/1±11/12) violence injuries (p=0.006 ms= 2/5±3/47) and total score of violence (p=0.038 ms= 47/6±33/68) were significantly higher in the group of partners dissatisfied from the pregnancy of their wives. However no significant differences were found between educational levels of men and women and different types of violence. Conclusion: The results indicate the correlation of verbal and physical violence as well as injuries during pregnancy with mother–infant attachment.